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Depression and the Brain’s Chemical Balance

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Everyone feels sad from time to time. But depression is much more than just feeling down. It's a real illness just like diabetes or heart disease. You can't just "snap out of it." Experts think that more than one thing causes depression. These include genes, biology, environment, and mental health. And chemical changes in the brain may add to the symptoms.


Brain chemicals and depression

The brain is a complex organ. It controls your whole body. This includes your emotions, too. It does this by sending messages from one nerve cell to another. Messages also travel inside the brain. They travel with help from chemicals. These are called neurotransmitters. No one knows exactly what happens in the brain to cause depression. But experts know that neurotransmitters are involved.

Closeup of synapse showing neurotransmitters between healthy neurons. Arrows show message moving along neurons.


Changes in the brain

Two neurotransmitters are mainly involved in depression. These are norepinephrine and serotonin. Medicines and talk therapy are the main treatments for depression. Both change the levels of these chemicals. In many cases, they ease symptoms of depression.

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